The major peptides found in Kambo and their primary researched or reported benefits include:

1. Dermorphin and Deltorphin

• What they are: Potent, naturally occurring opioid peptides.

  National Institutes of Health (NIH) | (.gov)

   

• Benefits: They bind strongly to opioid receptors in the brain, possessing pain-relieving properties many times more powerful than morphine. They can induce deep relaxation, mood elevation, and analgesia.

2. Phyllomedusin

• What it is: A peptide that strongly affects the smooth muscles and exocrine glands.

• Benefits: It directly triggers the physical purge (via emotional and physical release), stimulates salivary and tear glands, and causes contractions in the intestines.

3. Caerulein (Ceruletide) and Phyllocaerulein

• What they are: Peptides that stimulate the adrenal cortex and pituitary gland, heavily influencing pancreatic secretion, gastric acid production, and gut motility.

• Benefits: They contribute to deep visceral cleansing, blood pressure regulation, heightened sensory perception, and long-term stamina or energy boosts after the ceremony.

4. Sauvagine

• What it is: A peptide belonging to the corticotropin-releasing factor (CRF) family.

• Benefits: It deeply impacts the nervous system, influencing stress response, thermoregulation, blood pressure, and metabolic rate. It often triggers a powerful rush of warmth and energy throughout the body.

5. Phyllokinin and Bradykinin Derivatives

• What they are: Vasoactive peptides.

  ClinMed International Library

   

• Benefits: They cause powerful blood vessel dilation (vasodilation), lowering blood pressure and increasing vascular permeability. This allows the other peptides to be rapidly absorbed and carried efficiently through the lymphatic and circulatory systems.

  ClinMed International Library

   

6. Adenoregulin

• What it is: A peptide that interacts with human adenosine receptors (which are crucial for regulating heart rate, oxygen consumption, and neurological activity).

• Benefits: It has shown potential antimicrobial properties and works synergistically with the brain's neurotransmitter systems to open up deep states of mental clarity.

7. Dermaseptins

• What they are: Broad-spectrum antimicrobial peptides.

  MDPI

   

• Benefits: They are known for their powerful ability to combat bacteria, fungi, yeast, and viruses by disrupting microbial cell membranes, contributing to the immune-boosting properties attributed to the medicine.